Scenario Scientists from New Zealand have resolved a long-standing problem in regenerative medicine. Professor Li Ren-Choy from the National Institute of Medical Research and her team developed a new method to reprogram human cells to better mimic embryonic stem cells, with significant implications for biomedical and therapeutic uses. Her assistant, Dr Liev Green, writes an article about the new method on his blog, called ‘Green Cells’. Since 2001, non-reproductive adult cells of the body, called somatic cells, can be artificially reprogrammed into a state that resembles embryonic stem cells which have the capacity to then generate any cell of the body. These cells are called induced pluripotent stem cells. The problem that Professor Ren’s team solved relates to induced pluripotent stem cells’ tendency to retain an epigenetic memory of their original somatic state, as well as other epigenetic abnormalities. By way of solution, the team developed a new method, called TENT reprogramming, that mimics the reset of a cell’s epigenome (which ordinarily happens during very early embryonic development). Professor Li Ren-
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